Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase.

Gharbi-Ayachi, Aicha; Santhanakrishnan, Sridhar; Wong, Yee Hwa; Chan, Kitti W K; Tan, Siok Thing; Bates, Roderick W; Vasudevan, Subhash G; El Sahili, Abbas; Lescar, Julien

Gharbi-Ayachi, Aicha; Santhanakrishnan, Sridhar; Wong, Yee Hwa; Chan, Kitti W K; Tan, Siok Thing; Bates, Roderick W; Vasudevan, Subhash G; El Sahili, Abbas; Lescar, Julien.

Affiliation

Gharbi-Ayachi A; School of Biological Sciences, Nanyang Technological University, Singapore.
Santhanakrishnan S; Nanyang Institute of Structural Biology, Singapore.
Wong YH; School of Biological Sciences, Nanyang Technological University, Singapore.
Chan KWK; Nanyang Institute of Structural Biology, Singapore.
Tan ST; School of Biological Sciences, Nanyang Technological University, Singapore.
Bates RW; Nanyang Institute of Structural Biology, Singapore.
Vasudevan SG; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
El Sahili A; School of Biological Sciences, Nanyang Technological University, Singapore.
Lescar J; Nanyang Institute of Structural Biology, Singapore.

J Virol ; 94(21)2020 10 14.

Article in En | MEDLINE | ID: mdl-32796069

Subject(s)

Antiviral Agents/chemical synthesis; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Sulfones/chemical synthesis; Thiophenes/chemical synthesis; Viral Proteins/antagonists & inhibitors; Allosteric Regulation; Allosteric Site/drug effects; Amino Acid Sequence; Animals; Antiviral Agents/pharmacology; Binding Sites; Cell Line, Tumor; Cricetulus; Drug Design; Gene Expression; Hepatocytes; Humans; Kinetics; Models, Molecular; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; RNA-Dependent RNA Polymerase/chemistry; RNA-Dependent RNA Polymerase/genetics; RNA-Dependent RNA Polymerase/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Structure-Activity Relationship; Substrate Specificity; Sulfones/pharmacology; Thiophenes/pharmacology; Viral Proteins/chemistry; Viral Proteins/genetics; Viral Proteins/metabolism; Virus Replication/drug effects; Zika Virus/drug effects; Zika Virus/enzymology; Zika Virus/genetics; Zika Virus/isolation & purification; Zika Virus Infection/virology

Key words

RNA polymerases; Zika virus; nonstructural protein 5; polymerase inhibitors

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Sulfones / Thiophenes / Viral Proteins / RNA-Dependent RNA Polymerase Language: En Journal: J Virol Year: 2020 Type: Article Affiliation country: Singapore

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