Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.
JCI Insight
; 5(19)2020 10 02.
Article
in En
| MEDLINE
| ID: mdl-32853177
ABSTRACT
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approaches, we characterized the inflammatory responses in HS in depth, revealing immune responses centered on IFN-γ, IL-36, and TNF, with lesser contribution from IL-17A. We further identified B cells and plasma cells, with associated increases in immunoglobulin production and complement activation, as pivotal players in HS pathogenesis, with Bruton's tyrosine kinase (BTK) and spleen tyrosine kinase (SYK) pathway activation as a central signal transduction network in HS. These data provide preclinical evidence to accelerate the path toward clinical trials targeting BTK and SYK signaling in moderate-to-severe HS.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Plasma Cells
/
B-Lymphocytes
/
Biomarkers
/
Gene Expression Regulation
/
Hidradenitis Suppurativa
/
Proteome
/
Transcriptome
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
JCI Insight
Year:
2020
Type:
Article