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Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19.
Britton, Graham J; Chen-Liaw, Alice; Cossarini, Francesca; Livanos, Alexandra E; Spindler, Matthew P; Plitt, Tamar; Eggers, Joseph; Mogno, Ilaria; Gonzalez-Reiche, Ana S; Siu, Sophia; Tankelevich, Michael; Grinspan, Lauren Tal; Dixon, Rebekah E; Jha, Divya; van de Guchte, Adriana; Khan, Zenab; Martinez-Delgado, Gustavo; Amanat, Fatima; Hoagland, Daisy A; tenOever, Benjamin R; Dubinsky, Marla C; Merad, Miriam; van Bakel, Harm; Krammer, Florian; Bongers, Gerold; Mehandru, Saurabh; Faith, Jeremiah J.
Affiliation
  • Britton GJ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Chen-Liaw A; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Cossarini F; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Livanos AE; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Spindler MP; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Plitt T; Division of Infectious Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Eggers J; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Mogno I; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Gonzalez-Reiche AS; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Siu S; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Tankelevich M; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Grinspan LT; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Dixon RE; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Jha D; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • van de Guchte A; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Khan Z; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Martinez-Delgado G; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Amanat F; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Hoagland DA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • tenOever BR; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Dubinsky MC; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Merad M; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • van Bakel H; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Krammer F; The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Bongers G; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Mehandru S; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
  • Faith JJ; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
medRxiv ; 2020 Dec 09.
Article in En | MEDLINE | ID: mdl-32909002
ABSTRACT
We sought to characterize the role of the gastrointestinal immune system in the pathogenesis of the inflammatory response associated with COVID-19. We measured cytokines, inflammatory markers, viral RNA, microbiome composition and antibody responses in stool from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.
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Full text: 1 Database: MEDLINE Language: En Journal: MedRxiv Year: 2020 Type: Article
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Add to My VHL
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Full text: 1 Database: MEDLINE Language: En Journal: MedRxiv Year: 2020 Type: Article