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Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.
Ishii, Kazusa; Pouzolles, Marie; Chien, Christopher D; Erwin-Cohen, Rebecca A; Kohler, M Eric; Qin, Haiying; Lei, Haiyan; Kuhn, Skyler; Ombrello, Amanda K; Dulau-Florea, Alina; Eckhaus, Michael A; Shalabi, Haneen; Yates, Bonnie; Lichtenstein, Daniel A; Zimmermann, Valérie S; Kondo, Taisuke; Shern, Jack F; Young, Howard A; Taylor, Naomi; Shah, Nirali N; Fry, Terry J.
Affiliation
  • Ishii K; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Pouzolles M; Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), NIH, and.
  • Chien CD; Experimental Transplantation and Immunotherapy Branch, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
  • Erwin-Cohen RA; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Kohler ME; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Qin H; Cancer and Inflammation Program, Center for Cancer Research, NCI, NIH, Frederick, Maryland, USA.
  • Lei H; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Kuhn S; Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado, USA.
  • Ombrello AK; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Dulau-Florea A; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Eckhaus MA; CCR Collaborative Bioinformatics Resource (CCBR), Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
  • Shalabi H; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Yates B; Inflammatory Disease Section, National Human Genome Research Institute, NIH.
  • Lichtenstein DA; Department of Laboratory Medicine, NIH, and.
  • Zimmermann VS; Diagnostic and Research Services Branch, Division of Veterinary Resources, NIH, Bethesda, Maryland, USA.
  • Kondo T; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Shern JF; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Young HA; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Taylor N; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
  • Shah NN; Université de Montpellier, IGMM, CNRS, Montpellier, France.
  • Fry TJ; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), NIH.
J Clin Invest ; 130(10): 5425-5443, 2020 10 01.
Article in En | MEDLINE | ID: mdl-32925169

Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes / Immunotherapy, Adoptive / Perforin / Receptors, Chimeric Antigen Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2020 Type: Article

Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes / Immunotherapy, Adoptive / Perforin / Receptors, Chimeric Antigen Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2020 Type: Article