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Structural basis for the action of the drug trametinib at KSR-bound MEK.
Khan, Zaigham M; Real, Alexander M; Marsiglia, William M; Chow, Arthur; Duffy, Mary E; Yerabolu, Jayasudhan R; Scopton, Alex P; Dar, Arvin C.
Affiliation
  • Khan ZM; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Real AM; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Marsiglia WM; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Chow A; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Duffy ME; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Yerabolu JR; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Scopton AP; Department of Oncological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Dar AC; Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nature ; 588(7838): 509-514, 2020 12.
Article in En | MEDLINE | ID: mdl-32927473
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Full text: 1 Database: MEDLINE Main subject: Protein Kinases / Pyridones / Pyrimidinones / Mitogen-Activated Protein Kinase Kinases Limits: Animals / Humans Language: En Journal: Nature Year: 2020 Type: Article Affiliation country: United States
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Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Protein Kinases / Pyridones / Pyrimidinones / Mitogen-Activated Protein Kinase Kinases Limits: Animals / Humans Language: En Journal: Nature Year: 2020 Type: Article Affiliation country: United States