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The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme.
Gladkova, Elizaveta D; Nechepurenko, Ivan V; Bredikhin, Roman A; Chepanova, Arina A; Zakharenko, Alexandra L; Luzina, Olga A; Ilina, Ekaterina S; Dyrkheeva, Nadezhda S; Mamontova, Evgeniya M; Anarbaev, Rashid O; Reynisson, Jóhannes; Volcho, Konstantin P; Salakhutdinov, Nariman F; Lavrik, Olga I.
Affiliation
  • Gladkova ED; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Nechepurenko IV; Novosibirsk State University, Pirogova str. 1, Novosibirsk 630090, Russia.
  • Bredikhin RA; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Chepanova AA; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Zakharenko AL; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Luzina OA; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Ilina ES; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Dyrkheeva NS; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Mamontova EM; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Anarbaev RO; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Reynisson J; Novosibirsk State University, Pirogova str. 1, Novosibirsk 630090, Russia.
  • Volcho KP; Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
  • Salakhutdinov NF; School of Pharmacy and Bioengineering, Keele University, Hornbeam Building, Staffordshire ST5 5BG, UK.
  • Lavrik OI; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Akademika Lavrentieva Ave., Novosibirsk 630090, Russia.
Int J Mol Sci ; 21(19)2020 Sep 28.
Article in En | MEDLINE | ID: mdl-32998385
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Full text: 1 Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Berberine / Phosphoric Diester Hydrolases / Topotecan / Topoisomerase I Inhibitors / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: RUSSIA
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Berberine / Phosphoric Diester Hydrolases / Topotecan / Topoisomerase I Inhibitors / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: RUSSIA