Incorporating genomic signatures into surgical and medical decision-making for elderly glioblastoma patients.

Ene, Chibawanye I; Cimino, Patrick J; Fine, Howard A; Holland, Eric C

Ene, Chibawanye I; Cimino, Patrick J; Fine, Howard A; Holland, Eric C.

Affiliation

Ene CI; 1Department of Neurological Surgery, University of Washington School of Medicine.
Cimino PJ; 2Department of Pathology, Division of Neuropathology, University of Washington School of Medicine, Seattle, Washington.
Fine HA; 3Meyer Cancer Center, Division of Neuro-Oncology, Department of Neurology, NewYork-Presbyterian Hospital/Weill Cornell Medicine, New York, New York; and.
Holland EC; 4Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Neurosurg Focus ; 49(4): E11, 2020 10.

Article in En | MEDLINE | ID: mdl-33002863

Subject(s)

Brain Neoplasms; Glioblastoma; Aged; Antineoplastic Agents, Alkylating/therapeutic use; Brain Neoplasms/genetics; Brain Neoplasms/surgery; Clinical Decision-Making; Genomics; Glioblastoma/genetics; Glioblastoma/surgery; Humans; Prognosis; Prospective Studies; Quality of Life; Retrospective Studies

Key words

BEV = bevacizumab; CNS = central nervous system; EOR = extent of resection; GBM = glioblastoma; GGN = German Glioma Network; GTR = gross-total resection; IDH1/2 = isocitrate dehydrogenase 1/2; MGMT = [6]-methylguanine-DNA methyltransferase; OS = overall survival; PFS = progression-free survival; PR = partial resection; RT = radiation therapy; SCNA = somatic copy number alteration; SRS = stereotactic radiosurgery; STR = subtotal resection; SupTR = supratotal resection; TERTp = telomerase reverse transcriptase promoter; TMZ = temozolomide; VEGF = vascular endothelial growth factor; age; elderly; glioblastoma; gross-total resection; hypofractionated radiation therapy; somatic copy number alterations; supratotal resection; temozolomide

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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Humans Language: En Journal: Neurosurg Focus Journal subject: NEUROCIRURGIA Year: 2020 Type: Article

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