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Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Jacob, Fadi; Pather, Sarshan R; Huang, Wei-Kai; Zhang, Feng; Wong, Samuel Zheng Hao; Zhou, Haowen; Cubitt, Beatrice; Fan, Wenqiang; Chen, Catherine Z; Xu, Miao; Pradhan, Manisha; Zhang, Daniel Y; Zheng, Wei; Bang, Anne G; Song, Hongjun; Carlos de la Torre, Juan; Ming, Guo-Li.
Affiliation
  • Jacob F; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Medical Scientist Trainin
  • Pather SR; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Huang WK; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Zhang F; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Wong SZH; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Zhou H; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
  • Cubitt B; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Fan W; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Chen CZ; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA.
  • Xu M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA.
  • Pradhan M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA.
  • Zhang DY; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Zheng W; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892, USA.
  • Bang AG; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: abang@sbpdiscovery.org.
  • Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for
  • Carlos de la Torre J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: juanct@scripps.edu.
  • Ming GL; Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for
Cell Stem Cell ; 27(6): 937-950.e9, 2020 12 03.
Article in En | MEDLINE | ID: mdl-33010822

Full text: 1 Database: MEDLINE Main subject: Organoids / Choroid Plexus / Pluripotent Stem Cells / Viral Tropism / Neural Stem Cells / SARS-CoV-2 Type of study: Guideline Limits: Animals / Humans Language: En Journal: Cell Stem Cell Year: 2020 Type: Article

Full text: 1 Database: MEDLINE Main subject: Organoids / Choroid Plexus / Pluripotent Stem Cells / Viral Tropism / Neural Stem Cells / SARS-CoV-2 Type of study: Guideline Limits: Animals / Humans Language: En Journal: Cell Stem Cell Year: 2020 Type: Article