Health-related quality of life in Japanese low-risk prostate cancer patients choosing active surveillance: 3-year follow-up from PRIAS-JAPAN.
World J Urol
; 39(7): 2491-2497, 2021 Jul.
Article
in En
| MEDLINE
| ID: mdl-33079252
ABSTRACT
PURPOSE:
To evaluate the health-related quality of life (HRQoL) of Japanese men on active surveillance (AS) in the Prostate cancer Research International Active Surveillance study in Japan (PRIAS-JAPAN).METHODS:
Participants were included in the PRIAS-JAPAN HRQoL study between January 2010 and March 2016. Their general HRQoL was assessed using a validated Japanese version of the Short-Form 8 Health Survey (SF-8) at enrolment and annually thereafter until discontinuation of AS. The SF-8 mental component summary (MCS) and physical component summary (PCS) of men on AS were compared with scores of the general population (norm-based score [NBS] 50) and MCS and PCS scores for men following AS were analysed over time. We tested whether MCS and PCS scores over time explained discontinuation of AS.RESULTS:
Five hundred and twenty-five patients enrolled, and the median age at baseline was 68 years. At enrolment and after 1-, 2-, and 3-year follow-ups, the PCS and MCS scores were significantly higher than the NBS of the general Japanese population except for the median PCS at 3 years. We found that age at diagnosis and time on AS negatively affected the PCS score of men on AS, while every additional year on AS led to a 0.27 point increase in MCS scores. Neither PCS nor MCS were predictors for discontinuation of AS.CONCLUSION:
Japanese men following an AS strategy for 3 years reported better HRQoL compared with the general population, indicating that monitoring Japanese low-risk prostate cancer patients can be an effective treatment strategy. STUDY REGISTRATION Clinical trial registry-UMIN (University Hospital Medical Information Network); UMIN000002874 (2009/12/11).Key words
Full text:
1
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
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Quality of Life
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Patient Preference
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Watchful Waiting
Type of study:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limits:
Aged
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Humans
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Male
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Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
World J Urol
Year:
2021
Type:
Article
Affiliation country:
Japan