Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes.

Ivanov, S V; Ostrovskaya, R U; Sorokina, A V; Seredenin, S B

Ivanov, S V; Ostrovskaya, R U; Sorokina, A V; Seredenin, S B.

Affiliation

Ivanov SV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Ostrovskaya RU; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. rita.ostrovskaya@gmail.com.
Sorokina AV; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Seredenin SB; V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.

Bull Exp Biol Med ; 169(6): 783-786, 2020 Oct.

Article in En | MEDLINE | ID: mdl-33098515

Subject(s)

Anti-Anxiety Agents/pharmacology; Benzimidazoles/pharmacology; Diabetes Mellitus, Experimental/drug therapy; Hypoglycemic Agents/pharmacology; Morpholines/pharmacology; Neuroprotective Agents/pharmacology; Receptors, sigma/genetics; Animals; Blood Glucose/metabolism; Diabetes Mellitus, Experimental/chemically induced; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Experimental/pathology; Drug Repositioning; Gene Expression; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/metabolism; Insulin-Secreting Cells/pathology; Male; Rats; Rats, Wistar; Receptors, sigma/metabolism; Streptozocin; Treatment Outcome; Sigma-1 Receptor

Key words

Afobazole; cytoprotection; type 2 diabetes mellitus; ß cells; σ1-receptor

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Full text: 1 Database: MEDLINE Main subject: Anti-Anxiety Agents / Benzimidazoles / Morpholines / Receptors, sigma / Neuroprotective Agents / Diabetes Mellitus, Experimental / Hypoglycemic Agents Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2020 Type: Article Affiliation country: RUSSIA

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