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Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists.
Isbilir, Ali; Möller, Jan; Arimont, Marta; Bobkov, Vladimir; Perpiñá-Viciano, Cristina; Hoffmann, Carsten; Inoue, Asuka; Heukers, Raimond; de Graaf, Chris; Smit, Martine J; Annibale, Paolo; Lohse, Martin J.
Affiliation
  • Isbilir A; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
  • Möller J; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • Arimont M; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, 13125 Berlin, Germany.
  • Bobkov V; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • Perpiñá-Viciano C; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
  • Hoffmann C; Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.
  • Inoue A; argenx BVBA, Zwijnaarde 9052, Belgium.
  • Heukers R; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • de Graaf C; Institute of Molecular Cell Biology, University Hospital Jena, University of Jena, 07745 Jena, Germany.
  • Smit MJ; Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  • Annibale P; Institute of Molecular Cell Biology, University Hospital Jena, University of Jena, 07745 Jena, Germany.
  • Lohse MJ; Graduate School of Pharmaceutical Sciences, Tohoku University, 980-8578 Sendai, Japan.
Proc Natl Acad Sci U S A ; 117(46): 29144-29154, 2020 11 17.
Article in En | MEDLINE | ID: mdl-33148803
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Full text: 1 Database: MEDLINE Main subject: Dimerization / Receptors, CXCR4 / Microscopy, Fluorescence Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Dimerization / Receptors, CXCR4 / Microscopy, Fluorescence Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Type: Article Affiliation country: Germany