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Evolution and lineage dynamics of a transmissible cancer in Tasmanian devils.
Kwon, Young Mi; Gori, Kevin; Park, Naomi; Potts, Nicole; Swift, Kate; Wang, Jinhong; Stammnitz, Maximilian R; Cannell, Naomi; Baez-Ortega, Adrian; Comte, Sebastien; Fox, Samantha; Harmsen, Colette; Huxtable, Stewart; Jones, Menna; Kreiss, Alexandre; Lawrence, Clare; Lazenby, Billie; Peck, Sarah; Pye, Ruth; Woods, Gregory; Zimmermann, Mona; Wedge, David C; Pemberton, David; Stratton, Michael R; Hamede, Rodrigo; Murchison, Elizabeth P.
Affiliation
  • Kwon YM; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Gori K; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Park N; Wellcome Sanger Institute, Hinxton, United Kingdom.
  • Potts N; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Swift K; Mount Pleasant Laboratories, Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Prospect, Tasmania, Australia.
  • Wang J; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Stammnitz MR; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Cannell N; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Baez-Ortega A; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Comte S; School of Natural Sciences, University of Tasmania, Hobart, Tasmania, Australia.
  • Fox S; Vertebrate Pest Research Unit, NSW Department of Primary Industries, Orange, New South Wales, Australia.
  • Harmsen C; Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Save the Tasmanian Devil Program, Hobart, Tasmania, Australia.
  • Huxtable S; Toledo Zoo, Toledo, Ohio, United States of America.
  • Jones M; Mount Pleasant Laboratories, Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Prospect, Tasmania, Australia.
  • Kreiss A; Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Save the Tasmanian Devil Program, Hobart, Tasmania, Australia.
  • Lawrence C; School of Natural Sciences, University of Tasmania, Hobart, Tasmania, Australia.
  • Lazenby B; Menzies Institute, University of Tasmania, Hobart, Tasmania, Australia.
  • Peck S; Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Save the Tasmanian Devil Program, Hobart, Tasmania, Australia.
  • Pye R; Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Save the Tasmanian Devil Program, Hobart, Tasmania, Australia.
  • Woods G; Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Save the Tasmanian Devil Program, Hobart, Tasmania, Australia.
  • Zimmermann M; Menzies Institute, University of Tasmania, Hobart, Tasmania, Australia.
  • Wedge DC; Menzies Institute, University of Tasmania, Hobart, Tasmania, Australia.
  • Pemberton D; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Stratton MR; Oxford Big Data Institute, University of Oxford, Oxford, United Kingdom.
  • Hamede R; Tasmanian Department of Primary Industries, Parks, Water and the Environment (DPIPWE), Save the Tasmanian Devil Program, Hobart, Tasmania, Australia.
  • Murchison EP; Wellcome Sanger Institute, Hinxton, United Kingdom.
PLoS Biol ; 18(11): e3000926, 2020 11.
Article in En | MEDLINE | ID: mdl-33232318
ABSTRACT
Devil facial tumour 1 (DFT1) is a transmissible cancer clone endangering the Tasmanian devil. The expansion of DFT1 across Tasmania has been documented, but little is known of its evolutionary history. We analysed genomes of 648 DFT1 tumours collected throughout the disease range between 2003 and 2018. DFT1 diverged early into five clades, three spreading widely and two failing to persist. One clade has replaced others at several sites, and rates of DFT1 coinfection are high. DFT1 gradually accumulates copy number variants (CNVs), and its telomere lengths are short but constant. Recurrent CNVs reveal genes under positive selection, sites of genome instability, and repeated loss of a small derived chromosome. Cultured DFT1 cell lines have increased CNV frequency and undergo highly reproducible convergent evolution. Overall, DFT1 is a remarkably stable lineage whose genome illustrates how cancer cells adapt to diverse environments and persist in a parasitic niche.
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Full text: 1 Database: MEDLINE Main subject: Facial Neoplasms / Marsupialia Limits: Animals Country/Region as subject: Oceania Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: United kingdom
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Full text: 1 Database: MEDLINE Main subject: Facial Neoplasms / Marsupialia Limits: Animals Country/Region as subject: Oceania Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2020 Type: Article Affiliation country: United kingdom