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MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era.
Beckert, Patrick; Sanchez-Padilla, Elisabeth; Merker, Matthias; Dreyer, Viola; Kohl, Thomas A; Utpatel, Christian; Köser, Claudio U; Barilar, Ivan; Ismail, Nazir; Omar, Shaheed Vally; Klopper, Marisa; Warren, Robin M; Hoffmann, Harald; Maphalala, Gugu; Ardizzoni, Elisa; de Jong, Bouke C; Kerschberger, Bernhard; Schramm, Birgit; Andres, Sönke; Kranzer, Katharina; Maurer, Florian P; Bonnet, Maryline; Niemann, Stefan.
Affiliation
  • Beckert P; Molecular and Experimental Mycobacteriology, Research Center Borstel, Parkallee 1, 23845, Borstel, Germany.
  • Sanchez-Padilla E; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany.
  • Merker M; Epicentre, Paris, France.
  • Dreyer V; Molecular and Experimental Mycobacteriology, Research Center Borstel, Parkallee 1, 23845, Borstel, Germany.
  • Kohl TA; Molecular and Experimental Mycobacteriology, Research Center Borstel, Parkallee 1, 23845, Borstel, Germany.
  • Utpatel C; Molecular and Experimental Mycobacteriology, Research Center Borstel, Parkallee 1, 23845, Borstel, Germany.
  • Köser CU; Molecular and Experimental Mycobacteriology, Research Center Borstel, Parkallee 1, 23845, Borstel, Germany.
  • Barilar I; Department of Genetics, University of Cambridge, Cambridge, UK.
  • Ismail N; Molecular and Experimental Mycobacteriology, Research Center Borstel, Parkallee 1, 23845, Borstel, Germany.
  • Omar SV; Centre for Tuberculosis, National TB Reference Laboratory, WHO TB Supranational Laboratory Network, National Institute for Communicable Diseases/National Health Laboratory Services, Johannesburg, South Africa.
  • Klopper M; Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
  • Warren RM; Department of Internal Medicine, University of Witwatersrand, Johannesburg, South Africa.
  • Hoffmann H; Centre for Tuberculosis, National TB Reference Laboratory, WHO TB Supranational Laboratory Network, National Institute for Communicable Diseases/National Health Laboratory Services, Johannesburg, South Africa.
  • Maphalala G; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Ardizzoni E; South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • de Jong BC; DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Kerschberger B; South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Schramm B; SYNLAB Gauting, Gauting, Germany, IML red GmbH, Institute of Microbiology and Laboratory Medicine, WHO Supranational Reference Laboratory of TB, Gauting, Germany.
  • Andres S; National Tuberculosis Reference Laboratory (NTRL), Ministry of Health, Mbabane, Swaziland.
  • Kranzer K; Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Maurer FP; Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Bonnet M; Médecins Sans Frontières (MSF) - Eswatini, Mbabane, Eswatini.
  • Niemann S; Epicentre, Paris, France.
Genome Med ; 12(1): 104, 2020 11 25.
Article in En | MEDLINE | ID: mdl-33239092
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Full text: 1 Database: MEDLINE Main subject: Bacterial Proteins / Tuberculosis, Multidrug-Resistant / Diarylquinolines / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Guideline / Qualitative_research Limits: Humans Country/Region as subject: Africa Language: En Journal: Genome Med Year: 2020 Type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Bacterial Proteins / Tuberculosis, Multidrug-Resistant / Diarylquinolines / Mycobacterium tuberculosis / Antitubercular Agents Type of study: Guideline / Qualitative_research Limits: Humans Country/Region as subject: Africa Language: En Journal: Genome Med Year: 2020 Type: Article Affiliation country: Germany