Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine.

Vyhlidal, Carrie A; Chapron, Brian D; Ahmed, Atif; Singh, Vivekanand; Casini, Rebecca; Shakhnovich, Valentina

Vyhlidal, Carrie A; Chapron, Brian D; Ahmed, Atif; Singh, Vivekanand; Casini, Rebecca; Shakhnovich, Valentina.

Affiliation

Vyhlidal CA; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Chapron BD; Department of Pediatrics, University of Missouri - Kansas City School of Medicine, Kansas City, Missouri, USA.
Ahmed A; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Singh V; Department of Pediatrics, University of Missouri - Kansas City School of Medicine, Kansas City, Missouri, USA.
Casini R; Division of Pathology, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Shakhnovich V; Division of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.

Clin Transl Sci ; 14(2): 729-736, 2021 03.

Article in En | MEDLINE | ID: mdl-33278326

Subject(s)

Anti-Inflammatory Agents/pharmacokinetics; Crohn Disease/drug therapy; Cytochrome P-450 CYP3A/metabolism; Intestinal Mucosa/metabolism; Administration, Oral; Adolescent; Anti-Inflammatory Agents/administration & dosage; Biological Availability; Biopsy; Budesonide/administration & dosage; Budesonide/pharmacokinetics; Case-Control Studies; Child; Child, Preschool; Crohn Disease/immunology; Crohn Disease/pathology; Dose-Response Relationship, Drug; Duodenum/cytology; Duodenum/immunology; Duodenum/metabolism; Duodenum/pathology; Female; Humans; Ileum/cytology; Ileum/immunology; Ileum/metabolism; Ileum/pathology; Infant; Intestinal Absorption/immunology; Intestinal Mucosa/cytology; Intestinal Mucosa/pathology; Male; Models, Biological; Young Adult

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Full text: 1 Database: MEDLINE Main subject: Crohn Disease / Cytochrome P-450 CYP3A / Intestinal Mucosa / Anti-Inflammatory Agents Type of study: Observational_studies / Prognostic_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Clin Transl Sci Year: 2021 Type: Article Affiliation country: United States

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