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Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.
Bahadoer, Renu R; Dijkstra, Esmée A; van Etten, Boudewijn; Marijnen, Corrie A M; Putter, Hein; Kranenbarg, Elma Meershoek-Klein; Roodvoets, Annet G H; Nagtegaal, Iris D; Beets-Tan, Regina G H; Blomqvist, Lennart K; Fokstuen, Tone; Ten Tije, Albert J; Capdevila, Jaume; Hendriks, Mathijs P; Edhemovic, Ibrahim; Cervantes, Andrés; Nilsson, Per J; Glimelius, Bengt; van de Velde, Cornelis J H; Hospers, Geke A P.
Affiliation
  • Bahadoer RR; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
  • Dijkstra EA; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  • van Etten B; Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  • Marijnen CAM; Department of Radiation Oncology, Leiden University Medical Center, Leiden, Netherlands; Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands.
  • Putter H; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, Netherlands.
  • Kranenbarg EM; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
  • Roodvoets AGH; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
  • Nagtegaal ID; Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands.
  • Beets-Tan RGH; Department of Radiology, Netherlands Cancer Institute, Amsterdam, Netherlands.
  • Blomqvist LK; Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden.
  • Fokstuen T; Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden.
  • Ten Tije AJ; Department of Medical Oncology, Amphia Hospital, Breda, Netherlands.
  • Capdevila J; Department of Medical Oncology, Vall Hebron Institute of Oncology, Vall Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain.
  • Hendriks MP; Department of Medical Oncology, Northwest Clinics, Alkmaar, Netherlands.
  • Edhemovic I; Department of Surgical Oncology, Institute of Oncology Ljubljana, University of Ljubljana Faculty of Medicine, Ljubljana, Slovenia.
  • Cervantes A; Department of Medical Oncology, Biomedical Research Institute Incliva, University of Valencia, Valencia, Spain.
  • Nilsson PJ; Department of Surgery, Karolinska University Hospital, Stockholm, Sweden.
  • Glimelius B; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • van de Velde CJH; Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
  • Hospers GAP; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. Electronic address: sg.a.p.hospers@umcg.nl.
Lancet Oncol ; 22(1): 29-42, 2021 01.
Article in En | MEDLINE | ID: mdl-33301740
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Full text: 1 Database: MEDLINE Main subject: Rectal Neoplasms / Digestive System Surgical Procedures / Adenocarcinoma / Antineoplastic Combined Chemotherapy Protocols / Dose Fractionation, Radiation / Neoadjuvant Therapy / Chemoradiotherapy, Adjuvant Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do norte / Europa Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Netherlands
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Full text: 1 Database: MEDLINE Main subject: Rectal Neoplasms / Digestive System Surgical Procedures / Adenocarcinoma / Antineoplastic Combined Chemotherapy Protocols / Dose Fractionation, Radiation / Neoadjuvant Therapy / Chemoradiotherapy, Adjuvant Type of study: Clinical_trials Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: America do norte / Europa Language: En Journal: Lancet Oncol Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Netherlands