Physiologically-Based Pharmacokinetic Modeling of the Drug-Drug Interaction of the UGT Substrate Ertugliflozin Following Co-Administration with the UGT Inhibitor Mefenamic Acid.

Callegari, Ernesto; Lin, Jian; Tse, Susanna; Goosen, Theunis C; Sahasrabudhe, Vaishali

Callegari, Ernesto; Lin, Jian; Tse, Susanna; Goosen, Theunis C; Sahasrabudhe, Vaishali.

Affiliation

Callegari E; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Lin J; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Tse S; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Goosen TC; Department of Medicine Design-Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.
Sahasrabudhe V; Department of Clinical Pharmacology, Pfizer Global Research and Development, Pfizer Inc., Groton, Connecticut, USA.

CPT Pharmacometrics Syst Pharmacol ; 10(2): 127-136, 2021 02.

Article in En | MEDLINE | ID: mdl-33314761

Subject(s)

Bridged Bicyclo Compounds, Heterocyclic/pharmacokinetics; Cyclooxygenase Inhibitors/pharmacokinetics; Glucuronosyltransferase/metabolism; Mefenamic Acid/pharmacokinetics; Sodium-Glucose Transporter 2 Inhibitors/pharmacokinetics; Adult; Area Under Curve; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage; Bridged Bicyclo Compounds, Heterocyclic/metabolism; Cyclooxygenase Inhibitors/administration & dosage; Cyclooxygenase Inhibitors/metabolism; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Mefenamic Acid/administration & dosage; Mefenamic Acid/metabolism; Middle Aged; Models, Biological; Sodium-Glucose Transporter 2 Inhibitors/administration & dosage; Sodium-Glucose Transporter 2 Inhibitors/metabolism; UDP-Glucuronosyltransferase 1A9; Uridine/metabolism

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Full text: 1 Database: MEDLINE Main subject: Mefenamic Acid / Cyclooxygenase Inhibitors / Glucuronosyltransferase / Bridged Bicyclo Compounds, Heterocyclic / Sodium-Glucose Transporter 2 Inhibitors Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: CPT Pharmacometrics Syst Pharmacol Year: 2021 Type: Article Affiliation country: United States

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