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New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase.
Cheuka, Peter Mubanga; Centani, Luyanda; Arendse, Lauren B; Fienberg, Stephen; Wambua, Lynn; Renga, Shoneeze S; Dziwornu, Godwin Akpeko; Kumar, Malkeet; Lawrence, Nina; Taylor, Dale; Wittlin, Sergio; Coertzen, Dina; Reader, Janette; van der Watt, Mariette; Birkholtz, Lyn-Marie; Chibale, Kelly.
Affiliation
  • Cheuka PM; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Centani L; Department of Chemistry, University of Zambia, Great East Road Campus, P.O Box 32379, Lusaka, Zambia.
  • Arendse LB; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Fienberg S; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Wambua L; Drug Discovery and Development Centre (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Renga SS; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Dziwornu GA; Drug Discovery and Development Centre (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Kumar M; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Lawrence N; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Taylor D; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Wittlin S; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa.
  • Coertzen D; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.
  • Reader J; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.
  • van der Watt M; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.
  • Birkholtz LM; University of Basel, 4003 Basel, Switzerland.
  • Chibale K; Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria 0028, South Africa.
ACS Infect Dis ; 7(1): 34-46, 2021 01 08.
Article in En | MEDLINE | ID: mdl-33319990
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Full text: 1 Database: MEDLINE Main subject: Plasmodium / 1-Phosphatidylinositol 4-Kinase Type of study: Prognostic_studies Language: En Journal: ACS Infect Dis Year: 2021 Type: Article Affiliation country: South Africa
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Full text: 1 Database: MEDLINE Main subject: Plasmodium / 1-Phosphatidylinositol 4-Kinase Type of study: Prognostic_studies Language: En Journal: ACS Infect Dis Year: 2021 Type: Article Affiliation country: South Africa