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Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.
Brotherton-Pleiss, Christine; Yue, Peibin; Zhu, Yinsong; Nakamura, Kayo; Chen, Weiliang; Fu, Wenzhen; Kubota, Casie; Chen, Jasmine; Alonso-Valenteen, Felix; Mikhael, Simoun; Medina-Kauwe, Lali; Tius, Marcus A; Lopez-Tapia, Francisco; Turkson, James.
Affiliation
  • Brotherton-Pleiss C; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
  • Yue P; Medicinal Chemistry Leader, Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
  • Zhu Y; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
  • Chen W; Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
  • Fu W; Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
  • Kubota C; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
  • Chen J; Department of Chemistry, University of Hawaii, Manoa, 2545 McCarthy Mall, Honolulu, Hawaii 9682, United States.
  • Alonso-Valenteen F; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
  • Mikhael S; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
  • Medina-Kauwe L; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
  • Tius MA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
  • Lopez-Tapia F; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
  • Turkson J; Cancer Biology Program, University of Hawaii Cancer Center, University of Hawaii, Manoa, Honolulu, Hawaii 96813, United States.
J Med Chem ; 64(1): 695-710, 2021 01 14.
Article in En | MEDLINE | ID: mdl-33352047
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Full text: 1 Database: MEDLINE Main subject: Azetidines / STAT3 Transcription Factor Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Azetidines / STAT3 Transcription Factor Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Type: Article Affiliation country: United States