PASylated Thymosin &#945;1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology.

Binder, Uli; Skerra, Arne

PASylated Thymosin α1: A Long-Acting Immunostimulatory Peptide for Applications in Oncology and Virology.

Binder, Uli; Skerra, Arne.

Affiliation

Binder U; XL-Protein GmbH, Lise-Meitner-Str. 30, 85354 Freising, Germany.
Skerra A; Lehrstuhl für Biologische Chemie, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany.

Int J Mol Sci ; 22(1)2020 Dec 24.

Article in En | MEDLINE | ID: mdl-33374407

Subject(s)

Adjuvants, Immunologic/pharmacokinetics; Thymalfasin/pharmacokinetics; Acetylation; Acetyltransferases/metabolism; Adjuvants, Immunologic/genetics; Adjuvants, Immunologic/pharmacology; Animals; Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Female; Half-Life; Mass Spectrometry; Microscopy, Electron, Scanning; Neoplasms/drug therapy; Peptides/chemistry; Proteolysis; Rats; Rats, Wistar; Recombinant Fusion Proteins/blood; Recombinant Fusion Proteins/isolation & purification; Recombinant Fusion Proteins/pharmacokinetics; Recombinant Fusion Proteins/ultrastructure; Ribosomal Proteins/metabolism; Thymalfasin/blood; Thymalfasin/chemistry; Thymalfasin/genetics; Virus Diseases/drug therapy; COVID-19 Drug Treatment

Key words

COVID-19; PASylation; biobetter; cancer; drug delivery; half-life extension; immunostimulatory peptide; pharmacokinetics; thymosin alpha 1; viral disease

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Full text: 1 Database: MEDLINE Main subject: Adjuvants, Immunologic / Thymalfasin Limits: Animals Language: En Journal: Int J Mol Sci Year: 2020 Type: Article Affiliation country: Germany

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