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CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide.
Gurney, Mark; Stikvoort, Arwen; Nolan, Emma; Kirkham-McCarthy, Lucy; Khoruzhenko, Stanislav; Shivakumar, Rama; Zweegman, Sonja; Van de Donk, Niels W C J; Mutis, Tuna; Szegezdi, Eva; Sarkar, Subhashis; O'Dwyer, Michael.
Affiliation
  • Gurney M; National University of Ireland Galway, Galway.
  • Stikvoort A; Cancer Center Amsterdam, VU University Medical Center, Amsterdam.
  • Nolan E; National University of Ireland Galway, Galway.
  • Kirkham-McCarthy L; National University of Ireland Galway, Galway.
  • Khoruzhenko S; MaxCyte, Inc., Maryland.
  • Shivakumar R; MaxCyte, Inc., Maryland.
  • Zweegman S; Cancer Center Amsterdam, VU University Medical Center, Amsterdam.
  • Van de Donk NWCJ; Cancer Center Amsterdam, VU University Medical Center, Amsterdam.
  • Mutis T; Cancer Center Amsterdam, VU University Medical Center, Amsterdam.
  • Szegezdi E; National University of Ireland Galway, Galway.
  • Sarkar S; National University of Ireland Galway, Galway.
  • O'Dwyer M; National University of Ireland Galway, Galway. michael.odwyer@nuigalway.ie.
Haematologica ; 107(2): 437-445, 2022 02 01.
Article in En | MEDLINE | ID: mdl-33375774
Subject(s)
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Full text: 1 Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Immunotherapy, Adoptive / Receptors, Chimeric Antigen Limits: Humans Language: En Journal: Haematologica Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Immunotherapy, Adoptive / Receptors, Chimeric Antigen Limits: Humans Language: En Journal: Haematologica Year: 2022 Type: Article