Repurposing FDA-Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease.

Xu, Chenshu; Zou, Haoman; Yu, Xi; Xie, Yazhou; Cai, Jiaxin; Shang, Qi; Ouyang, Na; Wang, Yinan; Xu, Pan; He, Zhendan; Wu, Haiqiang

Xu, Chenshu; Zou, Haoman; Yu, Xi; Xie, Yazhou; Cai, Jiaxin; Shang, Qi; Ouyang, Na; Wang, Yinan; Xu, Pan; He, Zhendan; Wu, Haiqiang.

Affiliation

Xu C; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Zou H; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Yu X; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Xie Y; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Cai J; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Shang Q; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Ouyang N; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Wang Y; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Xu P; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
He Z; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.
Wu H; School of Pharmaceutical Sciences Health Science Center, Shenzhen University, 3688 Nanhai Road, Shenzhen, 518055, China.

ChemistryOpen ; 10(9): 877-881, 2021 09.

Article in En | MEDLINE | ID: mdl-33377311

Subject(s)

Aminoacyltransferases/antagonists & inhibitors; Drug Repositioning; Enzyme Inhibitors/chemistry; Small Molecule Libraries/chemistry; Alzheimer Disease/drug therapy; Aminoacyltransferases/metabolism; Crystallography, X-Ray; Enzyme Inhibitors/metabolism; Humans; Molecular Structure; Protein Binding; Small Molecule Libraries/metabolism; Structure-Activity Relationship

Key words

Alzheimer's disease; FDA-approved compounds; glutaminyl cyclase; oxidative stress; screening and repurposing

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Full text: 1 Database: MEDLINE Main subject: Aminoacyltransferases / Enzyme Inhibitors / Small Molecule Libraries / Drug Repositioning Limits: Humans Language: En Journal: ChemistryOpen Year: 2021 Type: Article Affiliation country: China

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