Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant <i>Mycobacterium tuberculosis</i> and bronchitis causing-bacteria.

Elsayed, Zainab M; Eldehna, Wagdy M; Abdel-Aziz, Marwa M; El Hassab, Mahmoud A; Elkaeed, Eslam B; Al-Warhi, Tarfah; Abdel-Aziz, Hatem A; Abou-Seri, Sahar M; Mohammed, Eman R

Development of novel isatin-nicotinohydrazide hybrids with potent activity against susceptible/resistant Mycobacterium tuberculosis and bronchitis causing-bacteria.

Elsayed, Zainab M; Eldehna, Wagdy M; Abdel-Aziz, Marwa M; El Hassab, Mahmoud A; Elkaeed, Eslam B; Al-Warhi, Tarfah; Abdel-Aziz, Hatem A; Abou-Seri, Sahar M; Mohammed, Eman R.

Affiliation

Elsayed ZM; Faculty of Pharmacy, Scientific Research and Innovation Support Unit, Kafrelsheikh University, Kafrelsheikh, Egypt.
Eldehna WM; Faculty of Pharmacy, Scientific Research and Innovation Support Unit, Kafrelsheikh University, Kafrelsheikh, Egypt.
Abdel-Aziz MM; Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Kafrelsheikh University, Kafrelsheikh, Egypt.
El Hassab MA; The Regional Center for Mycology & Biotechnology, Al-Azhar University, Cairo, Egypt.
Elkaeed EB; Department of Pharmaceutical Chemistry, School of Pharmacy, Badr University in Cairo, Badr City, Egypt.
Al-Warhi T; Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia.
Abdel-Aziz HA; Faculty of Pharmacy (Boys), Department of Pharmaceutical Organic Chemistry, Al-Azhar University, Cairo, Egypt.
Abou-Seri SM; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Mohammed ER; Department of Applied Organic Chemistry, National Research Center, Giza, Egypt.

J Enzyme Inhib Med Chem ; 36(1): 384-393, 2021 Dec.

Article in En | MEDLINE | ID: mdl-33406941

Subject(s)

Alcohol Oxidoreductases/antagonists & inhibitors; Anti-Bacterial Agents/chemical synthesis; Bacterial Proteins/antagonists & inhibitors; Drug Resistance, Bacterial/drug effects; Hydrazines/chemistry; Isatin/chemistry; Mycobacterium tuberculosis/enzymology; Alcohol Oxidoreductases/chemistry; Alcohol Oxidoreductases/metabolism; Anti-Bacterial Agents/pharmacology; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Binding Sites; Bordetella pertussis/chemistry; Bordetella pertussis/enzymology; Bordetella pertussis/isolation & purification; Bronchitis/drug therapy; Bronchitis/microbiology; Drug Design; Drug Resistance, Bacterial/genetics; Haemophilus influenzae/chemistry; Haemophilus influenzae/enzymology; Haemophilus influenzae/isolation & purification; Isoniazid/pharmacology; Klebsiella pneumoniae/chemistry; Klebsiella pneumoniae/enzymology; Klebsiella pneumoniae/isolation & purification; Microbial Sensitivity Tests; Molecular Docking Simulation; Moraxella catarrhalis/chemistry; Moraxella catarrhalis/enzymology; Moraxella catarrhalis/isolation & purification; Mycobacterium tuberculosis/chemistry; Mycobacterium tuberculosis/isolation & purification; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Streptococcus pneumoniae/chemistry; Streptococcus pneumoniae/enzymology; Streptococcus pneumoniae/isolation & purification; Streptomycin/pharmacology; Structure-Activity Relationship; Tuberculosis/drug therapy; Tuberculosis/microbiology

Key words

Anti-tubercular activity; DprE1 inhibitors; isatin derivatives; nicotinohydrazide; resistant TB

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Full text: 1 Database: MEDLINE Main subject: Bacterial Proteins / Drug Resistance, Bacterial / Alcohol Oxidoreductases / Hydrazines / Isatin / Anti-Bacterial Agents / Mycobacterium tuberculosis Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2021 Type: Article Affiliation country: Egypt

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