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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy.
Rehman, Sumaiyah K; Haynes, Jennifer; Collignon, Evelyne; Brown, Kevin R; Wang, Yadong; Nixon, Allison M L; Bruce, Jeffrey P; Wintersinger, Jeffrey A; Singh Mer, Arvind; Lo, Edwyn B L; Leung, Cherry; Lima-Fernandes, Evelyne; Pedley, Nicholas M; Soares, Fraser; McGibbon, Sophie; He, Housheng Hansen; Pollet, Aaron; Pugh, Trevor J; Haibe-Kains, Benjamin; Morris, Quaid; Ramalho-Santos, Miguel; Goyal, Sidhartha; Moffat, Jason; O'Brien, Catherine A.
Affiliation
  • Rehman SK; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Haynes J; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Collignon E; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.
  • Brown KR; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
  • Wang Y; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Nixon AML; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Bruce JP; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Wintersinger JA; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada; Vector Institute, Toronto, ON M5G 1M1, Canada.
  • Singh Mer A; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Lo EBL; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Leung C; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Lima-Fernandes E; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Pedley NM; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • Soares F; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada.
  • McGibbon S; Department of Physics, University of Toronto, Toronto, ON M5S 1A7, Canada.
  • He HH; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Pollet A; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada.
  • Pugh TJ; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Clinical Genomics Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
  • Haibe-Kains B; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
  • Morris Q; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, C
  • Ramalho-Santos M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: mrsantos@lunenfeld.ca.
  • Goyal S; Department of Physics, University of Toronto, Toronto, ON M5S 1A7, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address: goyal@physics.utoronto.ca.
  • Moffat J; Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3E1, Canada. Electronic address: j.moffat@utoronto.c
  • O'Brien CA; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Surgery, University Healt
Cell ; 184(1): 226-242.e21, 2021 01 07.
Article in En | MEDLINE | ID: mdl-33417860
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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Drug Resistance, Neoplasm / Diapause / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: Canada
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Drug Resistance, Neoplasm / Diapause / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: Canada