Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.

Geng, Hui; Lan, Rongpei; Liu, Yaguang; Chen, Wei; Wu, Meng; Saikumar, Pothana; Weinberg, Joel M; Venkatachalam, Manjeri A

Geng, Hui; Lan, Rongpei; Liu, Yaguang; Chen, Wei; Wu, Meng; Saikumar, Pothana; Weinberg, Joel M; Venkatachalam, Manjeri A.

Affiliation

Geng H; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Lan R; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Liu Y; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Chen W; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Wu M; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Saikumar P; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.
Weinberg JM; Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Venkatachalam MA; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas.

Am J Physiol Renal Physiol ; 320(3): F359-F374, 2021 03 01.

Article in En | MEDLINE | ID: mdl-33427061

Subject(s)

Acute Kidney Injury/metabolism; Cytokines/metabolism; Kidney Tubules, Proximal/metabolism; Receptors, Lysophosphatidic Acid/metabolism; Reperfusion Injury/metabolism; Acute Kidney Injury/genetics; Acute Kidney Injury/pathology; Animals; Cell Line; Connective Tissue Growth Factor/metabolism; Disease Models, Animal; ErbB Receptors/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Fibrosis; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; Kidney Tubules, Proximal/pathology; Lymphokines/metabolism; Male; Mice; Phosphorylation; Platelet-Derived Growth Factor/metabolism; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid/genetics; Reperfusion Injury/genetics; Reperfusion Injury/pathology; Signal Transduction; Transcription Factor AP-1/metabolism; Transforming Growth Factor beta1/metabolism

Key words

acute kidney injury; fibrosis; kidney; lysophosphatidic acid receptors

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Full text: 1 Database: MEDLINE Main subject: Reperfusion Injury / Cytokines / Receptors, Lysophosphatidic Acid / Acute Kidney Injury / Kidney Tubules, Proximal Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2021 Type: Article

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