Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells.

Hu, Ying-Huan; Li, Deng-Ke; Quan, Zheng-Yang; Wang, Cheng-Yu; Zhou, Ming; Sun, Zhen-Xiao

Hu, Ying-Huan; Li, Deng-Ke; Quan, Zheng-Yang; Wang, Cheng-Yu; Zhou, Ming; Sun, Zhen-Xiao.

Affiliation

Hu YH; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: 18234119066@163.com.
Li DK; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Quan ZY; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Wang CY; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Zhou M; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.
Sun ZX; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: sunzxcn@hotmail.com.

J Ethnopharmacol ; 270: 113845, 2021 Apr 24.

Article in En | MEDLINE | ID: mdl-33485974

Subject(s)

Chemical and Drug Induced Liver Injury/metabolism; Cytochrome P-450 CYP3A/genetics; Drugs, Chinese Herbal/toxicity; Fallopia multiflora/toxicity; Glucuronosyltransferase/genetics; Plant Roots/toxicity; Apoptosis/drug effects; Calcium/metabolism; Cell Line; Chemical and Drug Induced Liver Injury/genetics; Chemical and Drug Induced Liver Injury/pathology; Cytochrome P-450 CYP3A/drug effects; Drugs, Chinese Herbal/chemistry; Fallopia multiflora/chemistry; Gene Knockdown Techniques; Glucuronosyltransferase/drug effects; Hepatocytes/enzymology; Humans; Matrix Metalloproteinases/metabolism; Membrane Potential, Mitochondrial/drug effects; Metabolic Networks and Pathways/drug effects; Oxidative Stress/drug effects; Plant Roots/chemistry; Protein Interaction Maps/drug effects; RNA, Messenger/metabolism; RNA, Small Interfering/genetics; Reactive Oxygen Species/metabolism

Key words

Apoptosis; CYP3A4; Hepatotoxicity; Oxidative stress damage; Polygoni multiflori radix; RNA interference; UGT1A1

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Full text: 1 Database: MEDLINE Main subject: Drugs, Chinese Herbal / Glucuronosyltransferase / Plant Roots / Cytochrome P-450 CYP3A / Chemical and Drug Induced Liver Injury / Fallopia multiflora Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Ethnopharmacol Year: 2021 Type: Article

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