Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.

Ma, Wen-Qi; Sun, Xue-Jiao; Zhu, Yi; Liu, Nai-Feng

Ma, Wen-Qi; Sun, Xue-Jiao; Zhu, Yi; Liu, Nai-Feng.

Affiliation

Ma WQ; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University 87 Dingjiaqiao, Nanjing, 210009, PR China.
Sun XJ; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University 87 Dingjiaqiao, Nanjing, 210009, PR China.
Zhu Y; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University 87 Dingjiaqiao, Nanjing, 210009, PR China.
Liu NF; Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University 87 Dingjiaqiao, Nanjing, 210009, PR China. Electronic address: liunf@seu.edu.cn.

Free Radic Biol Med ; 165: 229-242, 2021 03.

Article in En | MEDLINE | ID: mdl-33513420

Subject(s)

Hyperlipidemias; Metformin; Vascular Calcification; Animals; Humans; Hyperlipidemias/drug therapy; Hyperlipidemias/etiology; Metformin/pharmacology; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Vascular Calcification/drug therapy; Vascular Calcification/etiology

Key words

Ferroptosis; Metformin; Periostin; Vascular calcification; p53

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Full text: 1 Database: MEDLINE Main subject: Vascular Calcification / Hyperlipidemias / Metformin Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2021 Type: Article

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