Intranasal delivery of experimental compounds in orthotopic brain tumor mouse models.
STAR Protoc
; 2(1): 100290, 2021 03 19.
Article
in En
| MEDLINE
| ID: mdl-33532737
Effective therapeutics for malignant primary brain tumors, such as glioblastomas (GBMs), are urgently needed. To facilitate and expedite early-phase GBM therapeutic development, we describe a protocol that allows the intranasal delivery of experimental compounds in GBM orthotopic mouse models. Compounds delivered through this route can bypass the blood-brain barrier and thus help validate effective therapeutic targets for GBMs. For complete details on the use and execution of this protocol, please refer to Pinkham et al. (2019).
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Glioma
/
Neoplasms, Experimental
Type of study:
Guideline
Limits:
Animals
/
Humans
Language:
En
Journal:
STAR Protoc
Year:
2021
Type:
Article
Affiliation country:
United States