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Long-QT founder variant T309I-Kv7.1 with dominant negative pattern may predispose delayed afterdepolarizations under ß-adrenergic stimulation.
Synková, Iva; Bébarová, Markéta; Andrsová, Irena; Chmelikova, Larisa; Svecová, Olga; Hosek, Jan; Pásek, Michal; Vít, Pavel; Valásková, Iveta; Gaillyová, Renata; Navrátil, Rostislav; Novotný, Tomás.
Affiliation
  • Synková I; Department of Medical Genetics, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00, Brno, Czech Republic.
  • Bébarová M; Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlárská 267/2, 611 37, Brno, Czech Republic.
  • Andrsová I; Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. mbebar@med.muni.cz.
  • Chmelikova L; Department of Internal Medicine and Cardiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00, Brno, Czech Republic.
  • Svecová O; Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology, Technická 10, 616 00, Brno, Czech Republic.
  • Hosek J; Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
  • Pásek M; Division of Biologically Active Complexes and Molecular Magnets, Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University in Olomouc, Slechtitelu 27, 783 71, Olomouc, Czech Republic.
  • Vít P; Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
  • Valásková I; Institute of Thermomechanics, Czech Academy of Sciences, Dolejskova 5, 182 00, Prague, Czech Republic.
  • Gaillyová R; Department of Paediatrics, University Hospital Brno and Faculty of Medicine, Masaryk University, Cernopolní 9, 613 00, Brno, Czech Republic.
  • Navrátil R; Department of Medical Genetics, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00, Brno, Czech Republic.
  • Novotný T; Department of Medical Genetics, University Hospital Brno and Faculty of Medicine, Masaryk University, Jihlavská 20, 625 00, Brno, Czech Republic.
Sci Rep ; 11(1): 3573, 2021 02 11.
Article in En | MEDLINE | ID: mdl-33574382
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Full text: 1 Database: MEDLINE Main subject: Long QT Syndrome / Adrenergic beta-Antagonists / Genetic Predisposition to Disease / KCNQ1 Potassium Channel Limits: Adult / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Sci Rep Year: 2021 Type: Article Affiliation country: Czech Republic
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Full text: 1 Database: MEDLINE Main subject: Long QT Syndrome / Adrenergic beta-Antagonists / Genetic Predisposition to Disease / KCNQ1 Potassium Channel Limits: Adult / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Sci Rep Year: 2021 Type: Article Affiliation country: Czech Republic