Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17.

Alabi, Rolake O; Lora, Jose; Celen, Arda B; Maretzky, Thorsten; Blobel, Carl P

Alabi, Rolake O; Lora, Jose; Celen, Arda B; Maretzky, Thorsten; Blobel, Carl P.

Affiliation

Alabi RO; Tri-Institutional MD/PhD Program, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medicine, Rockefeller University, New York, NY 10021, USA.
Lora J; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.
Celen AB; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.
Maretzky T; Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY 10021, USA.
Blobel CP; Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

Int J Mol Sci ; 22(4)2021 Feb 12.

Article in En | MEDLINE | ID: mdl-33673337

Subject(s)

ADAM10 Protein/metabolism; ADAM17 Protein/metabolism; Amyloid Precursor Protein Secretases/metabolism; Embryo, Mammalian/metabolism; Fibroblasts/metabolism; Membrane Proteins/metabolism; Proteolysis; Receptor, Notch1/metabolism; ADAM10 Protein/genetics; ADAM17 Protein/genetics; Amyloid Precursor Protein Secretases/genetics; Animals; Membrane Proteins/genetics; Mice; Mice, Knockout; Receptor, Notch1/genetics

Key words

ADAM10; ADAM17; Notch pathway; Notch receptor; Notch1; cell signaling; intercellular signaling; juxtacrine signaling; proteolysis; regulation

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Full text: 1 Database: MEDLINE Main subject: Embryo, Mammalian / Receptor, Notch1 / Amyloid Precursor Protein Secretases / Proteolysis / Fibroblasts / ADAM10 Protein / ADAM17 Protein / Membrane Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Int J Mol Sci Year: 2021 Type: Article Affiliation country: United States

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