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Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity.
Hu, Ziying; Zhang, Chengdong; Wang, Shuai; Gao, Siqi; Wei, Jingjing; Li, Miaomiao; Hou, Linghui; Mao, Huilin; Wei, Yanyan; Qi, Tao; Liu, Hongmao; Liu, Dong; Lan, Feng; Lu, Daru; Wang, Hongyan; Li, Jixi; Wang, Yongming.
Affiliation
  • Hu Z; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Zhang C; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Wang S; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • Gao S; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Wei J; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Li M; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Hou L; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Mao H; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Wei Y; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Qi T; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Liu H; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Liu D; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135,China.
  • Lan F; School of Life Sciences, Co-innovation Center of Neuroregeneration, Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China.
  • Lu D; State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
  • Wang H; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
  • Li J; NHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning, Science and Technology Research Institute, Chongqing, 400020, China.
  • Wang Y; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200438, China.
Nucleic Acids Res ; 49(7): 4008-4019, 2021 04 19.
Article in En | MEDLINE | ID: mdl-33721016
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Full text: 1 Database: MEDLINE Main subject: Staphylococcus / Bacterial Proteins / CRISPR-Cas Systems / CRISPR-Associated Protein 9 Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2021 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Staphylococcus / Bacterial Proteins / CRISPR-Cas Systems / CRISPR-Associated Protein 9 Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2021 Type: Article Affiliation country: China