All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping.
Nano Lett
; 21(7): 3184-3190, 2021 04 14.
Article
in En
| MEDLINE
| ID: mdl-33734716
ABSTRACT
The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Surgical Mesh
/
Optogenetics
Limits:
Animals
Language:
En
Journal:
Nano Lett
Year:
2021
Type:
Article