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Inverse association of plasma hydrogen sulfide levels with visceral fat area among Chinese young men: a cross-sectional study.
Fan, Dongmei; Huang, Huiyan; Wang, Xing; Liu, Junru; Liu, Bowei; Yin, Fuzai.
Affiliation
  • Fan D; Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
  • Huang H; Department of Endocrinology, Dalian Hospital affiliated to Shengjing Hospital of China Medical University, Shenyang, China.
  • Wang X; Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
  • Liu J; Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
  • Liu B; Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China.
  • Yin F; Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China, yinfu_zai@163.com.
Arch Endocrinol Metab ; 65(3): 269-276, 2021 Nov 03.
Article in En | MEDLINE | ID: mdl-33740335
ABSTRACT

OBJECTIVE:

To investigate the association between plasma Hydrogen Sulfide (H2S) levels and visceral fat area (VFA) among Chinese young men.

METHODS:

This cross-sectional study involved 156 Chinese male subjects, aged 18-45 years, who visited the First Hospital of Qinhuangdao (Hebei, China) in 2014 for annual health check-up. Participants were categorized into low (VFA < 75.57 cm2), medium (75.57 cm2 ≤ VFA<100.37 cm2), and high (VFA ≥ 100.37 cm2) (n = 52/group). We estimated VFA and plasma H2S levels by using bioelectrical impedance analysis and a fluorescence probe-based approach, respectively. The associations of H2S with VFA and obesity anthropometric measures were assessed.

RESULTS:

In the high VFA group, the body mass index (BMI, 30.4 ± 2.45 kg/m2), total body fat (TBF, 27.9 ± 3.23 kg), plasma H2S (3.5 µmol/L), free fatty acid (FFA, 0.6 ± 0.24 mmol/L), triglyceride (TG, 2.0 mmol/L), and total cholesterol (TC, 5.5 ± 1.02 mmol/L) levels were significantly higher than that of those of the low and medium VFA groups, respectively (P < 0.05). Plasma H2S levels were found to be inversely correlated with VFA, TBF, waist circumference, BMI, FFA, LnFINS, LnHOMA-IR, LnTG, TC, and LDL-C (P < 0.05). Multiple backward stepwise regression analysis revealed an inverse correlation of plasma H2S levels with FFA (ß = -0.214, P = 0.005) and VFA (ß = -0.429, P < 0.001), independent of adiposity measures and other confounding factors.

CONCLUSION:

VFA was independently and inversely associated with plasma H2S levels among Chinese young men. Therefore, determining plasma H2S levels could aid in the assessment of abnormal VAT distribution.
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Full text: 1 Database: MEDLINE Main subject: Hydrogen Sulfide Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans / Male Country/Region as subject: Asia Language: En Journal: Arch Endocrinol Metab Year: 2021 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Hydrogen Sulfide Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Humans / Male Country/Region as subject: Asia Language: En Journal: Arch Endocrinol Metab Year: 2021 Type: Article Affiliation country: China