SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca<sup>2</sup>.

Lai, Alex L; Freed, Jack H

SARS-CoV-2 Fusion Peptide has a Greater Membrane Perturbating Effect than SARS-CoV with Highly Specific Dependence on Ca².

Lai, Alex L; Freed, Jack H.

Affiliation

Lai AL; ACERT, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, United States.
Freed JH; ACERT, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, United States. Electronic address: jhf3@cornell.edu.

J Mol Biol ; 433(10): 166946, 2021 05 14.

Article in En | MEDLINE | ID: mdl-33744314

Subject(s)

Calcium/metabolism; Cell Membrane/metabolism; SARS-CoV-2/metabolism; Severe acute respiratory syndrome-related coronavirus/metabolism; Spike Glycoprotein, Coronavirus/metabolism; Viral Fusion Proteins/metabolism; Amino Acid Sequence; Binding Sites; Calcium/pharmacology; Calorimetry; Cell Membrane/drug effects; Cell Membrane/virology; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Severe acute respiratory syndrome-related coronavirus/drug effects; SARS-CoV-2/drug effects; Spike Glycoprotein, Coronavirus/chemistry; Spike Glycoprotein, Coronavirus/genetics; Thermodynamics; Viral Fusion Proteins/chemistry; Viral Fusion Proteins/genetics; Virus Internalization/drug effects

Key words

COVID-19; ESR; ITC; hydrophobicity; ion specificity

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Cell Membrane / Viral Fusion Proteins / Calcium / Severe acute respiratory syndrome-related coronavirus / Spike Glycoprotein, Coronavirus / SARS-CoV-2 Type of study: Prognostic_studies Language: En Journal: J Mol Biol Year: 2021 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google