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Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome.
Grange, Robert M H; Sharma, Rohit; Shah, Hardik; Reinstadler, Bryn; Goldberger, Olga; Cooper, Marissa K; Nakagawa, Akito; Miyazaki, Yusuke; Hindle, Allyson G; Batten, Annabelle J; Wojtkiewicz, Gregory R; Schleifer, Grigorij; Bagchi, Aranya; Marutani, Eizo; Malhotra, Rajeev; Bloch, Donald B; Ichinose, Fumito; Mootha, Vamsi K; Zapol, Warren M.
Affiliation
  • Grange RMH; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Sharma R; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Shah H; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Reinstadler B; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Goldberger O; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Cooper MK; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Nakagawa A; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Miyazaki Y; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Hindle AG; School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV, USA.
  • Batten AJ; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Wojtkiewicz GR; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Schleifer G; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Bagchi A; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Marutani E; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Malhotra R; Cardiology Division and Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Bloch DB; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard M
  • Ichinose F; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Mootha VK; Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: vamsi@hms.harvard.edu.
  • Zapol WM; Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: wzapol@mgh.harvard.edu.
Mol Genet Metab ; 133(1): 83-93, 2021 05.
Article in En | MEDLINE | ID: mdl-33752971
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Full text: 1 Database: MEDLINE Main subject: Oxygen / Brain / Leigh Disease / Electron Transport Complex I / NAD Limits: Animals / Humans Language: En Journal: Mol Genet Metab Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Year: 2021 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Oxygen / Brain / Leigh Disease / Electron Transport Complex I / NAD Limits: Animals / Humans Language: En Journal: Mol Genet Metab Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / METABOLISMO Year: 2021 Type: Article Affiliation country: United States