Distinct functional and structural connections predict crystallised and fluid cognition in healthy adults.
Hum Brain Mapp
; 42(10): 3102-3118, 2021 07.
Article
in En
| MEDLINE
| ID: mdl-33830577
ABSTRACT
White matter pathways between neurons facilitate neuronal coactivation patterns in the brain. Insight into how these structural and functional connections underlie complex cognitive functions provides an important foundation with which to delineate disease-related changes in cognitive functioning. Here, we integrate neuroimaging, connectomics, and machine learning approaches to explore how functional and structural brain connectivity relate to cognition. Specifically, we evaluate the extent to which functional and structural connectivity predict individual crystallised and fluid cognitive abilities in 415 unrelated healthy young adults (202 females) from the Human Connectome Project. We report three main findings. First, we demonstrate functional connectivity is more predictive of cognitive scores than structural connectivity, and, furthermore, integrating the two modalities does not increase explained variance. Second, we show the quality of cognitive prediction from connectome measures is influenced by the choice of grey matter parcellation, and, possibly, how that parcellation is derived. Third, we find that distinct functional and structural connections predict crystallised and fluid abilities. Taken together, our results suggest that functional and structural connectivity have unique relationships with crystallised and fluid cognition and, furthermore, studying both modalities provides a more comprehensive insight into the neural correlates of cognition.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cerebral Cortex
/
Cognition
/
Connectome
/
Intelligence
/
Nerve Net
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Hum Brain Mapp
Journal subject:
CEREBRO
Year:
2021
Type:
Article
Affiliation country:
United States