Hydrogen sulfide prevents ethanol-induced ZO-1 CpG promoter hypermethylation-dependent vascular permeability via miR-218/DNMT3a axis.

Behera, Jyotirmaya; Kelly, Kimberly E; Tyagi, Neetu

Behera, Jyotirmaya; Kelly, Kimberly E; Tyagi, Neetu.

Affiliation

Behera J; Department of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Kelly KE; Department of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Tyagi N; Department of Physiology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.

J Cell Physiol ; 236(10): 6852-6867, 2021 10.

Article in En | MEDLINE | ID: mdl-33855696

Subject(s)

Brain/blood supply; Capillary Permeability/drug effects; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methylation/drug effects; Endothelial Cells/drug effects; Ethanol/toxicity; Hydrogen Sulfide/pharmacology; MicroRNAs/metabolism; Zonula Occludens-1 Protein/metabolism; Animals; Cell Line; CpG Islands; DNA (Cytosine-5-)-Methyltransferases/genetics; DNA Methyltransferase 3A; Endothelial Cells/enzymology; Endothelial Cells/pathology; Energy Metabolism/drug effects; Epigenesis, Genetic/drug effects; Homocysteine/metabolism; Mice; MicroRNAs/genetics; Mitochondria/drug effects; Mitochondria/metabolism; Mitochondria/pathology; Oxidative Stress/drug effects; Promoter Regions, Genetic; Zonula Occludens-1 Protein/genetics

Key words

epigenetic CpG DNA methylation; homocysteine; miRNA regulation; tight junction protein; vascular permeability

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Full text: 1 Database: MEDLINE Main subject: Brain / Capillary Permeability / DNA Methylation / MicroRNAs / Endothelial Cells / Ethanol / DNA (Cytosine-5-)-Methyltransferases / Zonula Occludens-1 Protein / Hydrogen Sulfide Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cell Physiol Year: 2021 Type: Article Affiliation country: United States

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