Positive Selection in the Light Zone of Germinal Centers.
Front Immunol
; 12: 661678, 2021.
Article
in En
| MEDLINE
| ID: mdl-33868314
ABSTRACT
Germinal centers (GCs) are essential sites for the production of high-affinity antibody secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of vaccination. Affinity maturation and permissive selection in GCs are key for the production of PCs and MBCs, respectively. For these purposes, GCs positively select "fit" cells in the light zone of the GC and instructs them for one of three known B cell fates PCs, MBCs and persistent GC-B cells as dark zone entrants. In this review, we provide an overview of the positive selection process and discuss its mechanisms and how B cell fates are instructed.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Plasma Cells
/
B-Lymphocytes
/
Cell Differentiation
/
Germinal Center
/
Immunologic Memory
/
Antibodies
Limits:
Animals
/
Humans
Language:
En
Journal:
Front Immunol
Year:
2021
Type:
Article
Affiliation country:
United kingdom