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Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis.
Holthof, Lisa C; van der Schans, Jort J; Katsarou, Afroditi; Poels, Renée; Gelderloos, Anne T; Drent, Esther; van Hal-van Veen, Susan E; Li, Fengzhi; Zweegman, Sonja; van de Donk, Niels W C J; Themeli, Maria; Groen, Richard W J; Mutis, Tuna.
Affiliation
  • Holthof LC; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • van der Schans JJ; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Katsarou A; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Poels R; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Gelderloos AT; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Drent E; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • van Hal-van Veen SE; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Li F; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  • Zweegman S; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • van de Donk NWCJ; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Themeli M; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Groen RWJ; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.
  • Mutis T; Department of Hematology, Amsterdam UMC, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands. t.mutis@amsterdamumc.nl.
Clin Cancer Res ; 27(13): 3793-3803, 2021 07 01.
Article in En | MEDLINE | ID: mdl-33883175
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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Immunotherapy, Adoptive / Apoptosis / Mesenchymal Stem Cells / Receptors, Chimeric Antigen / Multiple Myeloma Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Netherlands
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Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Immunotherapy, Adoptive / Apoptosis / Mesenchymal Stem Cells / Receptors, Chimeric Antigen / Multiple Myeloma Type of study: Prognostic_studies Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2021 Type: Article Affiliation country: Netherlands