Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT-0 (Isocaldarchaeol)*.
Angew Chem Int Ed Engl
; 60(32): 17491-17496, 2021 08 02.
Article
in En
| MEDLINE
| ID: mdl-33930240
ABSTRACT
Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature. These amphiphiles are the major constituents of the membranes of numerous Archaea, some of which are extremophilic organisms. Due to their unique structures, there has been significant interest in studying both the biophysical properties and the biosynthesis of these molecules. However, these studies have thus far been hampered by limited access to chemically pure samples. Herein, we report a concise and stereoselective synthesis of the archaeal tetraether lipid parallel GDGT-0 and the synthesis and self-assembly of derivatives bearing different polar groups.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Glyceryl Ethers
/
Membrane Lipids
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2021
Type:
Article
Affiliation country:
United States