Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection.
Immunol Res
; 69(3): 255-263, 2021 06.
Article
in En
| MEDLINE
| ID: mdl-33939124
ABSTRACT
Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Papillomavirus Infections
/
Alphapapillomavirus
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
Language:
En
Journal:
Immunol Res
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2021
Type:
Article
Affiliation country:
France