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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
Pettinato, Anthony M; Yoo, Dasom; VanOudenhove, Jennifer; Chen, Yu-Sheng; Cohn, Rachel; Ladha, Feria A; Yang, Xiulan; Thakar, Ketan; Romano, Robert; Legere, Nicolas; Meredith, Emily; Robson, Paul; Regnier, Michael; Cotney, Justin L; Murry, Charles E; Hinson, J Travis.
Affiliation
  • Pettinato AM; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
  • Yoo D; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA.
  • VanOudenhove J; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
  • Chen YS; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Cohn R; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Ladha FA; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
  • Yang X; Center for Cardiovascular Biology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.
  • Thakar K; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Romano R; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Legere N; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Meredith E; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Robson P; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
  • Regnier M; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA.
  • Cotney JL; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA.
  • Murry CE; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Department of Pathology, University of Washington, Seattle, WA 98109, USA; Depart
  • Hinson JT; Department of Genetics and Genome Sciences, UConn Health, Farmington, CT 06030, USA; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Electronic address: travis.hinson@jax.org.
Cell Rep ; 35(5): 109088, 2021 05 04.
Article in En | MEDLINE | ID: mdl-33951429
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Full text: 1 Database: MEDLINE Main subject: Sarcomeres / DNA Damage / Tumor Suppressor Protein p53 Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Sarcomeres / DNA Damage / Tumor Suppressor Protein p53 Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2021 Type: Article Affiliation country: United States