Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development.

Perelli, Robin M; O'Sullivan, Matthew L; Zarnick, Samantha; Kay, Jeremy N

Perelli, Robin M; O'Sullivan, Matthew L; Zarnick, Samantha; Kay, Jeremy N.

Affiliation

Perelli RM; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA.
O'Sullivan ML; Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA.
Zarnick S; Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA.
Kay JN; Ophthalmology Residency Program, Duke University School of Medicine, Durham, NC 27710, USA.

Development ; 148(9)2021 05 01.

Article in En | MEDLINE | ID: mdl-33960384

Subject(s)

Astrocytes/metabolism; Cell Proliferation/physiology; Neovascularization, Pathologic/metabolism; Neovascularization, Physiologic/physiology; Oxygen/metabolism; Retina/growth & development; Animals; Animals, Newborn; Astrocytes/cytology; Astrocytes/drug effects; Cell Proliferation/drug effects; Female; Hypoxia/metabolism; Mice; Neovascularization, Physiologic/drug effects; Oxygen/pharmacology; Retina/abnormalities; Retina/metabolism; Retina/pathology; Retinal Vessels/metabolism; Retinopathy of Prematurity

Key words

Astrocyte; Development; Hypoxia; Mouse; Oxygen-induced retinopathy; Retina; Retinopathy of prematurity

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Full text: 1 Database: MEDLINE Main subject: Oxygen / Retina / Astrocytes / Neovascularization, Physiologic / Cell Proliferation / Neovascularization, Pathologic Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Development Journal subject: BIOLOGIA / EMBRIOLOGIA Year: 2021 Type: Article Affiliation country: United States

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