A novel biodegradable injectable chitosan hydrogel for overcoming postoperative trauma and combating multiple tumors.
Carbohydr Polym
; 265: 118065, 2021 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-33966829
ABSTRACT
Wound bacterial infections and tumor recurrence are the main reasons for the poor prognosis after primary tumor resection. Here, we fabricated a novel therapeutic nanocomposite using chitosan (CS) hydrogel combined with black phosphate nanosheets (BPNSs) and in situ grown copper nanoparticles (CuNPs). The obtained hydrogel (CS@BPNSs@CuNPs), possessing a remarkable temperature-sensitive spongy-like state, offered 24.98 % blood clotting index. The released BPNSs@CuNPs could produce reactive oxygen species (ROS) to kill infected invasive bacteria (98.1 %) and inhibit local residual tumor cell regeneration (11.3 %). Moreover, by coupling the photothermal properties of BPNSs, the BPNSs@CuNPs showed 19.6 % penetration rate to cross the blood tumor barrier (BTB) for treating brain tumors. The hydrogel platform was further combined with aPD-L1-based immunotherapy to employ its synergetic therapeutic effect in the prevention of tumors. The in vivo studies showed that biodegradable hydrogel could hold a great potential as a novel strategy for improving postoperative therapy and multi-tumor treatments.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Surgical Wound Infection
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Copper
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Hydrogels
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Chitosan
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Nanocomposites
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Neoplasms
Limits:
Animals
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Humans
Language:
En
Journal:
Carbohydr Polym
Year:
2021
Type:
Article
Affiliation country:
Denmark