Outer Membrane Vesicles of Vibrio cholerae Protect and Deliver Active Cholera Toxin to Host Cells via Porin-Dependent Uptake.

Zingl, Franz G; Thapa, Himadri B; Scharf, Martina; Kohl, Paul; Müller, Anna M; Schild, Stefan

Zingl, Franz G; Thapa, Himadri B; Scharf, Martina; Kohl, Paul; Müller, Anna M; Schild, Stefan.

Affiliation

Zingl FG; Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Thapa HB; Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Scharf M; Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Kohl P; Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Müller AM; Institute of Molecular Biosciences, University of Graz, Graz, Austria.
Schild S; Institute of Molecular Biosciences, University of Graz, Graz, Austria.

mBio ; 12(3): e0053421, 2021 06 29.

Article in En | MEDLINE | ID: mdl-34076466

Subject(s)

Bacterial Outer Membrane Proteins/metabolism; Cholera Toxin/metabolism; Epithelial Cells/microbiology; Porins/metabolism; Vibrio cholerae/metabolism; Animals; Biological Transport; Caco-2 Cells; Epithelial Cells/metabolism; HT29 Cells; Humans; Mice; Mice, Inbred C57BL; Secretory Vesicles/metabolism; Vibrio cholerae/pathogenicity; Virulence Factors

Key words

OmpT; OmpU; Vibrio cholerae; cargo; cholera toxin; gastrointestinal tract; human intestinal cells; internalization; outer membrane vesicles; rhodamine; trypsin; virulence

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Full text: 1 Database: MEDLINE Main subject: Bacterial Outer Membrane Proteins / Vibrio cholerae / Cholera Toxin / Porins / Epithelial Cells Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: MBio Year: 2021 Type: Article Affiliation country: Austria

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