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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Xian, Hongxu; Liu, Yuan; Rundberg Nilsson, Alexandra; Gatchalian, Raphaella; Crother, Timothy R; Tourtellotte, Warren G; Zhang, Yi; Aleman-Muench, German R; Lewis, Gavin; Chen, Weixuan; Kang, Sarah; Luevanos, Melissa; Trudler, Dorit; Lipton, Stuart A; Soroosh, Pejman; Teijaro, John; de la Torre, Juan Carlos; Arditi, Moshe; Karin, Michael; Sanchez-Lopez, Elsa.
Affiliation
  • Xian H; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.
  • Liu Y; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.
  • Rundberg Nilsson A; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.
  • Gatchalian R; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.
  • Crother TR; Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Tourtellotte WG; Departments of Pathology, Neurology, Neurological Surgery and Biomedical Sciences, Cedars-Sinai Medical Center. Los Angeles, CA 90048, USA; Samuel Oschin Cancer Center, Cedars-Sinai Medical Center. Los Angeles, CA 90048, USA.
  • Zhang Y; Departments of Pathology, Neurology, Neurological Surgery and Biomedical Sciences, Cedars-Sinai Medical Center. Los Angeles, CA 90048, USA.
  • Aleman-Muench GR; CVM discovery, Immunometabolism, Janssen Research & Development, San Diego CA 92121, USA.
  • Lewis G; CVM discovery, Immunometabolism, Janssen Research & Development, San Diego CA 92121, USA.
  • Chen W; Janssen Research & Development, LLC, San Diego, CA, USA.
  • Kang S; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.
  • Luevanos M; Neurodegeneration New Medicines Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Trudler D; Neurodegeneration New Medicines Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Lipton SA; Neurodegeneration New Medicines Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
  • Soroosh P; CVM discovery, Immunometabolism, Janssen Research & Development, San Diego CA 92121, USA.
  • Teijaro J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • de la Torre JC; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Arditi M; Departments of Biomedical Sciences and Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Karin M; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA. Electronic address: karinoffice@ucsd.edu.
  • Sanchez-Lopez E; Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.
Immunity ; 54(7): 1463-1477.e11, 2021 07 13.
Article in En | MEDLINE | ID: mdl-34115964
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Full text: 1 Database: MEDLINE Main subject: Pneumonia / DNA, Mitochondrial / Adenosine Triphosphate / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / Metformin Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Pneumonia / DNA, Mitochondrial / Adenosine Triphosphate / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / Metformin Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: United States