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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Sanchez, Carlos G; Acker, Christopher M; Gray, Audrey; Varadarajan, Malini; Song, Cheng; Cochran, Nadire R; Paula, Steven; Lindeman, Alicia; An, Shaojian; McAllister, Gregory; Alford, John; Reece-Hoyes, John; Russ, Carsten; Craig, Lucas; Capre, Ketthsy; Doherty, Christian; Hoffman, Gregory R; Luchansky, Sarah J; Polydoro, Manuela; Dolmetsch, Ricardo; Elwood, Fiona.
Affiliation
  • Sanchez CG; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Acker CM; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Gray A; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Varadarajan M; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Song C; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Cochran NR; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Paula S; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Lindeman A; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • An S; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • McAllister G; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Alford J; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Reece-Hoyes J; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Russ C; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Craig L; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Capre K; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Doherty C; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Hoffman GR; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Luchansky SJ; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Polydoro M; Vertex Pharmaceuticals, Boston, MA, USA.
  • Dolmetsch R; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
  • Elwood F; Department of Neuroscience, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.
Commun Biol ; 4(1): 736, 2021 06 14.
Article in En | MEDLINE | ID: mdl-34127790
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Full text: 1 Database: MEDLINE Main subject: Tau Proteins / Metabolic Networks and Pathways / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Commun Biol Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Tau Proteins / Metabolic Networks and Pathways / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Commun Biol Year: 2021 Type: Article Affiliation country: United States