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High-resolution structure of the vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine for treating acquired TTP.
Lee, Hyun Tae; Park, Ui Beom; Jeong, Tae Jun; Gu, Nahyeon; Lee, Sang Hyung; Kim, Yujin; Heo, Yong-Seok.
Affiliation
  • Lee HT; Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029. Republic of Korea.
  • Park UB; Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029. Republic of Korea.
  • Jeong TJ; Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029. Republic of Korea.
  • Gu N; Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029. Republic of Korea.
  • Lee SH; Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029. Republic of Korea.
  • Kim Y; Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029. Republic of Korea.
  • Heo YS; Department of Chemistry, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029. Republic of Korea. Electronic address: ysheo@konkuk.ac.kr.
Biochem Biophys Res Commun ; 567: 49-55, 2021 08 27.
Article in En | MEDLINE | ID: mdl-34144500
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Full text: 1 Database: MEDLINE Main subject: Purpura, Thrombotic Thrombocytopenic / Von Willebrand Factor / Single-Domain Antibodies Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Purpura, Thrombotic Thrombocytopenic / Von Willebrand Factor / Single-Domain Antibodies Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2021 Type: Article