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Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Schwabenland, Marius; Salié, Henrike; Tanevski, Jovan; Killmer, Saskia; Lago, Marilyn Salvat; Schlaak, Alexandra Emilia; Mayer, Lena; Matschke, Jakob; Püschel, Klaus; Fitzek, Antonia; Ondruschka, Benjamin; Mei, Henrik E; Boettler, Tobias; Neumann-Haefelin, Christoph; Hofmann, Maike; Breithaupt, Angele; Genc, Nafiye; Stadelmann, Christine; Saez-Rodriguez, Julio; Bronsert, Peter; Knobeloch, Klaus-Peter; Blank, Thomas; Thimme, Robert; Glatzel, Markus; Prinz, Marco; Bengsch, Bertram.
Affiliation
  • Schwabenland M; Institute of Neuropathology and Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Salié H; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Tanevski J; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University, Heidelberg, Germany.
  • Killmer S; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Lago MS; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Schlaak AE; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Mayer L; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Matschke J; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Püschel K; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fitzek A; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Ondruschka B; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Mei HE; German Rheumatism Research Center Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.
  • Boettler T; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Neumann-Haefelin C; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Hofmann M; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Breithaupt A; Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.
  • Genc N; Institute of Neuropathology, University of Goettingen, Goettingen, Germany.
  • Stadelmann C; Institute of Neuropathology, University of Goettingen, Goettingen, Germany.
  • Saez-Rodriguez J; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University, Heidelberg, Germany.
  • Bronsert P; Institute for Surgical Pathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.
  • Knobeloch KP; Institute of Neuropathology and Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Blank T; Institute of Neuropathology and Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Thimme R; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.
  • Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Prinz M; Institute of Neuropathology and Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany; Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. Electronic address: marco.prinz@uniklinik-freiburg.de.
  • Bengsch B; Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany; Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. Electronic address: bertram.bengsc
Immunity ; 54(7): 1594-1610.e11, 2021 07 13.
Article in En | MEDLINE | ID: mdl-34174183
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Full text: 1 Database: MEDLINE Main subject: Brain / Microglia / CD8-Positive T-Lymphocytes / COVID-19 Limits: Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Brain / Microglia / CD8-Positive T-Lymphocytes / COVID-19 Limits: Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Type: Article Affiliation country: Germany