Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies.
Cancer Res
; 81(19): 4889-4895, 2021 10 01.
Article
in En
| MEDLINE
| ID: mdl-34215623
ABSTRACT
We systematically reviewed and synthesized evidence on the impact of physical activity/exercise on cancer treatment efficacy. We included six preclinical and seven clinical studies. Exercise significantly enhanced the efficacy of chemotherapy and tamoxifen in seven of eight rodent models in either an additive, sensitizing, or synergistic manner. In clinical studies, preliminary evidence indicates that exercise during neoadjuvant, primary, and adjuvant treatment may enhance efficacy of cancer therapies; however, no clinical study was designed for this purpose. Here we discuss the biological mechanisms of exercise-associated enhancement of therapeutic efficacy and propose future research directions to definitively examine the effects of exercise on cancer treatment and patient outcomes.
Full text:
1
Database:
MEDLINE
Main subject:
Exercise
/
Exercise Therapy
/
Neoplasms
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
Cancer Res
Year:
2021
Type:
Article
Affiliation country:
Canada