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Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade.
Andrews, Miles C; Duong, Connie P M; Gopalakrishnan, Vancheswaran; Iebba, Valerio; Chen, Wei-Shen; Derosa, Lisa; Khan, Md Abdul Wadud; Cogdill, Alexandria P; White, Michael G; Wong, Matthew C; Ferrere, Gladys; Fluckiger, Aurélie; Roberti, Maria P; Opolon, Paule; Alou, Maryam Tidjani; Yonekura, Satoru; Roh, Whijae; Spencer, Christine N; Curbelo, Irina Fernandez; Vence, Luis; Reuben, Alexandre; Johnson, Sarah; Arora, Reetakshi; Morad, Golnaz; Lastrapes, Matthew; Baruch, Erez N; Little, Latasha; Gumbs, Curtis; Cooper, Zachary A; Prieto, Peter A; Wani, Khalida; Lazar, Alexander J; Tetzlaff, Michael T; Hudgens, Courtney W; Callahan, Margaret K; Adamow, Matthew; Postow, Michael A; Ariyan, Charlotte E; Gaudreau, Pierre-Olivier; Nezi, Luigi; Raoult, Didier; Mihalcioiu, Catalin; Elkrief, Arielle; Pezo, Rossanna C; Haydu, Lauren E; Simon, Julie M; Tawbi, Hussein A; McQuade, Jennifer; Hwu, Patrick; Hwu, Wen-Jen.
Affiliation
  • Andrews MC; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Duong CPM; Olivia Newton-John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, Victoria, Australia.
  • Gopalakrishnan V; Deparment of Medicine, Monash University, Melbourne, Victoria, Australia.
  • Iebba V; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Chen WS; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Derosa L; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Khan MAW; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Cogdill AP; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • White MG; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Wong MC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ferrere G; Department of Dermatology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
  • Fluckiger A; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Roberti MP; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Opolon P; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Alou MT; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Yonekura S; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Roh W; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Spencer CN; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Curbelo IF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Vence L; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Reuben A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Johnson S; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Arora R; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Morad G; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Lastrapes M; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Baruch EN; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Little L; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Gumbs C; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Cooper ZA; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Prieto PA; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Wani K; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Lazar AJ; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Tetzlaff MT; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Hudgens CW; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Callahan MK; Gustave Roussy Cancer Campus (GRCC), Villejuif, France.
  • Adamow M; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France.
  • Postow MA; Université Paris-Saclay, Faculté de Médecine Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
  • Ariyan CE; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Gaudreau PO; Department of Informatics, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.
  • Nezi L; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Raoult D; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Mihalcioiu C; Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Elkrief A; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Pezo RC; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Haydu LE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Simon JM; MD Anderson Cancer Center University of Texas Health Graduate School of Biomedical Sciences (GSBS), Houston, TX, USA.
  • Tawbi HA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • McQuade J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Hwu P; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Hwu WJ; AstraZeneca, Gaithersburg, MD, USA.
Nat Med ; 27(8): 1432-1441, 2021 08.
Article in En | MEDLINE | ID: mdl-34239137
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Full text: 1 Database: MEDLINE Main subject: CTLA-4 Antigen / Programmed Cell Death 1 Receptor / Gastrointestinal Microbiome Type of study: Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: CTLA-4 Antigen / Programmed Cell Death 1 Receptor / Gastrointestinal Microbiome Type of study: Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2021 Type: Article Affiliation country: United States